pro Caspase 7 Rabbit mAb [zR8x]Cat NO.: A11199

Protein names ：apoptosis-related cysteine peptidase; Apoptotic protease Mch-3; CASP-7; Caspase-7 subunit p11; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3;

UniProtID ：P55210

MASS(da) ：34,277

MW(kDa) ：34kDa

Form ：Liquid

Purification ：Affinity-chromatography

Host ：Rabbit

Isotype ： IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• 免疫荧光(ICC/IF)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with A synthesized peptide derived from human pro Caspase 7

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Jurkat cell lysate.

Function ： Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed:8521391, PubMed:8576161, PubMed:8567622, PubMed:9070923, PubMed:11701129). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:8521391, PubMed:8576161, PubMed:8567622, PubMed:9070923). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death (PubMed:8521391, PubMed:8576161, PubMed:8567622, PubMed:9070923). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity).., [Isoform Beta]: Lacks enzymatic activity..

Tissue specificity ：Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.

Subcellular locationi ：Cytoplasm.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.