ZNRF2 Rabbit mAb [f84K]Cat NO.: A37439

Protein names ：E3 ubiquitin-protein ligase ZNRF2; ZNRF2; Zinc/RING finger protein 2; RNF202; Protein Ells2;

UniProtID ：Q8NHG8

MASS(da) ：24,115

MW(kDa) ：24kDa

Form ：Liquid

Purification ：Affinity-chromatography

Host ：Rabbit

Isotype ： IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with A synthesized peptide derived from human ZNRF2

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：HeLa cell lysate.

Function ： May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates..

Tissue specificity ：Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney..

Subcellular locationi ：Endosome membrane,Peripheral membrane protein. Lysosome membrane,Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane,Peripheral membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.