RbAp48 Rabbit mAb [8KBp]Cat NO.: A85358

Protein names ：CAF I p48; CAF-I p48; NURF55; RBAP48; RBBP4;

UniProtID ：Q09028

MASS(da) ：47,656

MW(kDa) ：48kDa

Form ：Liquid

Purification ：Affinity-chromatography

Host ：Rabbit

Isotype ： IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• 免疫荧光(ICC/IF)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with A synthesized peptide derived from human RbAp48

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Jurkat cell lysate.

Function ： Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair,the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression,the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling,the PRC2 complex, which promotes repression of homeotic genes during development,and the NURF (nucleosome remodeling factor) complex..

Tissue specificity ：Expressed in neuroblastoma cells..

Subcellular locationi ：Nucleus. Chromosome, telomere.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.