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ROS1 Rabbit mAb [OHMT]Cat NO.: A45097

Western blot(SDS PAGE) analysis of extracts from recombinant ROS1.Using ROS1 Rabbit mAb [OHMT] at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :ROS1,MCF3,ROS,ROS1_HUMAN,Proto-oncogene tyrosine-protein kinase ROS

UniProtID :P08922

MASS(da) :263,915

MW(kDa) :258、110、50-80 kDa

Form :Liquid

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity :Human

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human ROS1

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :recombinant ROS1

Function : Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2..

Tissue specificity :Expressed in brain. Expression is increased in primary gliomas..

Subcellular locationi :Cell membrane,Single-pass type I membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.