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Western blot(SDS PAGE) analysis of extracts from (1) HeLa cell lysate; (2) Mouse spleen lysate.Using USP22 Rabbit mAb [P5rl]at dilution of 1:1000 incubated at 4℃ over night.
Protein names :Ubiquitin carboxyl terminal hydrolase 22; Usp22; USP3L;
UniProtID :Q9UPT9
MASS(da) :59,961
MW(kDa) :60kDa
Form :Liquid
Purification :Affinity-chromatography
Host :Rabbit
Isotype : IgG
sensitivity :Endogenous
Reactivity :Human,Mouse,Rat
Specificity :Antibody is produced by immunizing animals with A synthesized peptide derived from human USP22
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :(1) HeLa cell lysate; (2) Mouse spleen lysate.
Function : Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression..
Tissue specificity :Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver..
Subcellular locationi :Nucleus.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.