Tin2 Rabbit mAb [Om6Q]Cat NO.: A62678

Protein names ：DKCA3; Tin 2; TIN2; TINF 2; Tinf2;

UniProtID ：Q9BSI4

MASS(da) ：50,023

MW(kDa) ：40kDa

Form ：Liquid

Purification ：Affinity-chromatography

Host ：Rabbit

Isotype ： IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with A synthesized peptide derived from human Tin2

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：(1) HUVEC cell lysate; (2) NIH/3T3 cell lysate; (3) PC12 cell lysate.

Function ： Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends,without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix..

Tissue specificity ：Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Subcellular locationi ：Nucleus. Chromosome, telomere.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.