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TEAD1/2/3/4 Rabbit mAb [dCpG]Cat NO.: A24045

Western blot(SDS PAGE) analysis of extracts from SW480 cell lysate.Using TEAD1/2/3/4 Rabbit mAb [dCpG]at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :DTEF 1; NTEF 1; TCF13; TEAD1; TEAD2; TEAD3; TEAD4; TEAD5; TEF1; TEF4; TEF5;

UniProtID :P28347/Q15561/Q15562/Q99594

MASS(da) :47,946

MW(kDa) :54kDa

Form :Liquid

Purification :Affinity-chromatography

Host :Rabbit

Isotype : IgG

sensitivity :Endogenous

Reactivity :Human

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with A synthesized peptide derived from human TEAD1 + TEAD2 + TEAD3 + TEAD4

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :SW480 cell lysate.

Function : Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif..

Tissue specificity :Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Subcellular locationi :Nucleus.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.