Desmoplakin Rabbit mAb [PLlb]Cat NO.: A21268

Protein names ：Desmoplakin I; Desmoplakin II; DPI; DPII; DSP; KPPS2; PPKS2;

UniProtID ：P15924

MASS(da) ：331,774

MW(kDa) ：270kDa

Form ：Liquid

Purification ：Affinity-chromatography

Host ：Rabbit

Isotype ： IgG

sensitivity ：Endogenous

Reactivity ：Human Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫荧光(ICC/IF)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with A synthesized peptide derived from human Desmoplakin

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：A431 cell lysate.

Function ： Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

Tissue specificity ：Expressed in oral mucosa (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528)..,[Isoform DPI]: Apparently an obligate constituent of all desmosomes.,[Isoform DPII]: Resides predominantly in tissues and cells of stratified origin.

Subcellular locationi ：Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.