VAMP7 Rabbit mAb [AY4L]Cat NO.: A46782

Protein names ：VAMP7,SYBL1,VAMP7_HUMAN,Vesicle-associated membrane protein 7

UniProtID ：P51809

MASS(da) ：24,935

MW(kDa) ：25 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human VAMP7

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：A172 cells

Function ： Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation..

Tissue specificity ：Detected in all tissues tested.

Subcellular locationi ：Cytoplasmic vesicle, secretory vesicle membrane,Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane,Single-pass type IV membrane protein. Late endosome membrane,Single-pass type IV membrane protein. Lysosome membrane,Single-pass type IV membrane protein. Endoplasmic reticulum membrane,Single-pass type IV membrane protein. Cytoplasmic vesicle, phagosome membrane,Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.