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Western blot(SDS PAGE) analysis of extracts from HepG2 cells.Using Miz-1 Rabbit mAb [4RMV] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :ZBTB17,MIZ1,ZNF151,ZNF60,ZBT17_HUMAN,Zinc finger and BTB domain-containing protein 17
UniProtID :Q13105
MASS(da) :87,928
MW(kDa) :95 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human Miz-1
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :HepG2 cells
Function : Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription,this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946)..
Tissue specificity :Expressed in germinal center B-cells..
Subcellular locationi :Nucleus.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.