SOCS7 Rabbit mAb [Ot5K]Cat NO.: A13289

Protein names ：Ash and phospholipase C gamma-binding protein; NAP4; Nck; Nck Ash and phospholipase C binding protein; Nck associated protein 4; NCKAP4; SH2 domain containing SOCS box protein;SOCS4; SOCS6; Socs7; Suppressor of cytokine signaling 7;

UniProtID ：O14512

MASS(da) ：62,969

MW(kDa) ：63kDa

Form ：Liquid

Purification ：Affinity-chromatography

Host ：Rabbit

Isotype ： IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with A synthesized peptide derived from human SOCS7

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：HeLa cell lysate.

Function ： Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)..

Tissue specificity ：Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain..

Subcellular locationi ：Cytoplasm. Cell membrane,Peripheral membrane protein,Cytoplasmic side. Nucleus.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.