P-AMPA Receptor 1 (GluA1) (S831) Rabbit mAb [6986]Cat NO.: A80835

Protein names ：GRIA1,GLUH1,GLUR1,GRIA1_HUMAN,Glutamate receptor 1

UniProtID ：P42261

MASS(da) ：101,506

MW(kDa) ：100 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human Phospho-AMPA Receptor 1 (GluA1) (Ser831)

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Mouse brain

Function ： Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate..

Tissue specificity ：Widely expressed in brain.

Subcellular locationi ：Cell membrane,Multi-pass membrane protein. Endoplasmic reticulum membrane,Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane,Multi-pass membrane protein. Cell junction, synapse, postsynaptic density membrane,Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Early endosome membrane,Multi-pass membrane protein. Recycling endosome membrane,Multi-pass membrane protein. Cell junction, synapse, presynapse. Cell junction, synapse.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.