delta 2 Catenin Rabbit mAb [ih6f]Cat NO.: A87290

Protein names ：ARM-repeat protein;Catenin delta 2;CTNND 2; Ctnnd2; Delta catenin; Delta-catenin;GT24; Neural plakophilin related arm repeat protein; Neurojungin; NPRAP; T cell delta catenin;

UniProtID ：O35927(mouse)(human:Q9UQB3)

MASS(da) ：135,000

MW(kDa) ：135kDa

Form ：Liquid

Purification ：Affinity-chromatography

Host ：Rabbit

Isotype ： IgG

sensitivity ：Endogenous

Reactivity ：Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫荧光(ICC/IF)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with A synthesized peptide derived from human delta 2 Catenin

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Mouse brain cell lysate.

Function ： Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:17993462) (PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (PubMed:15282317)..

Tissue specificity ：Expressed in neurons and glial cells. Isoform 2 was found to be the most predominant isoform in various brain regions. Expressed at neuromuscular junctions..

Subcellular locationi ：Nucleus. Cell junction, adherens junction. Cell projection, dendrite. Perikaryon.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.