P-Phospholamban (S16) Rabbit mAb [x6hZ]Cat NO.: A46354

Protein names ：Cardiac phospholamban; CMD1P; CMH18; PLB; Pln;

UniProtID ：P26678

MASS(da) ：6,109

MW(kDa) ：11kDa

Form ：Liquid

Purification ：Affinity-chromatography

Host ：Rabbit

Isotype ： IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with A synthesized peptide derived from human Phospho-Phospholamban (S16)

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：various lysates

Function ： Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation..

Tissue specificity ：Heart muscle (at protein level)..

Subcellular locationi ：Endoplasmic reticulum membrane,Single-pass membrane protein. Sarcoplasmic reticulum membrane,Single-pass membrane protein. Mitochondrion membrane,Single-pass membrane protein. Membrane,Single-pass membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.