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Western blot(SDS PAGE) analysis of extracts from A431 cells.Using proCathepsin DRabbit mAb [5VQZ] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :CTSD,CPSD,CATD_HUMAN,Cathepsin D [Cleaved into: Cathepsin D light chain,Cathepsin D heavy chain]
UniProtID :P07339
MASS(da) :44,552
MW(kDa) :44 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human proCathepsin D
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :A431 cells
Function : Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease..
Tissue specificity :Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530)..
Subcellular locationi :Lysosome. Melanosome. Secreted, extracellular space.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.