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proCathepsin D Rabbit mAb [5VQZ]Cat NO.: A49276

Western blot(SDS PAGE) analysis of extracts from A431 cells.Using proCathepsin DRabbit mAb [5VQZ] at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :CTSD,CPSD,CATD_HUMAN,Cathepsin D [Cleaved into: Cathepsin D light chain,Cathepsin D heavy chain]

UniProtID :P07339

MASS(da) :44,552

MW(kDa) :44 kDa

Form :Liquid

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity :Human

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • 免疫组化(IHC)1:100
  • 免疫荧光(ICC/IF) 1:100
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human proCathepsin D

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :A431 cells

Function : Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease..

Tissue specificity :Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530)..

Subcellular locationi :Lysosome. Melanosome. Secreted, extracellular space.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.