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LAMP1 Rabbit mAb [9J95]Cat NO.: A54981

Western blot(SDS PAGE) analysis of extracts from HeLa cells.Using LAMP1Rabbit mAb [9J95] at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :LAMP1,LAMP1_HUMAN,Lysosome-associated membrane glycoprotein 1

UniProtID :P11279

MASS(da) :44,882

MW(kDa) :110 kDa

Form :Liquid

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity :Human

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • 免疫组化(IHC)1:100
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human LAMP1

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :HeLa cells

Function : Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity). Plays also an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.., (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085). Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).., (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F..

Subcellular locationi :Cell membrane,Single-pass type I membrane protein. Endosome membrane,Single-pass type I membrane protein. Lysosome membrane,Single-pass type I membrane protein. Late endosome membrane,Single-pass type I membrane protein. Cytolytic granule membrane,Single-pass type I membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.