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Western blot(SDS PAGE) analysis of extracts from Daudi cells.Using GBP1Rabbit mAb [3L7X] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :GBP1,GBP1_HUMAN,Guanylate-binding protein 1
UniProtID :P32455
MASS(da) :67,931
MW(kDa) :68 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human GBP1
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :Daudi cells
Function : Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions (By similarity). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity). Promotes IFN-gamma-mediated host defense against bacterial infections by regulating bacteriolytic peptide generation via its interaction with ubiquitin-binding protein SQSTM1, which delivers monoubiquitylated proteins to autolysosomes for the generation of bacteriolytic peptides (By similarity). Exhibits antiviral activity against influenza virus (PubMed:22106366)..
Subcellular locationi :Cytoplasm. Golgi apparatus membrane,Lipid-anchor,Cytoplasmic side. Cell membrane. Secreted. Cytoplasmic vesicle.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.