IL-1RA Rabbit mAb [O28J]Cat NO.: A47016

Protein names ：IL1RN,IL1F3,IL1RA,IL1RA_HUMAN,Interleukin-1 receptor antagonist protein

UniProtID ：P18510

MASS(da) ：20,055

MW(kDa) ：19 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human IL-1RA

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：A431 cells

Function ： Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2,however, the physiological relevance of the latter association is unsure..

Tissue specificity ：The intracellular form of IL1RN is predominantly expressed in epithelial cells.

Subcellular locationi ：[Isoform 1]: Secreted.,[Isoform 2]: Cytoplasm.,[Isoform 3]: Cytoplasm.,[Isoform 4]: Cytoplasm.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.