* 产品详情- */>
Western blot(SDS PAGE) analysis of extracts from 293T cells.Using FKBP38Rabbit mAb [HIHM] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :FKBP8,FKBP38,FKBP8_HUMAN,Peptidyl-prolyl cis-trans isomerase FKBP8
UniProtID :Q14318
MASS(da) :44,562
MW(kDa) :52 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human FKBP38
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :293T cells
Function : Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis..
Tissue specificity :Widely expressed. Highest levels seen in the brain. Highly abundant in the retina..
Subcellular locationi :Mitochondrion. Mitochondrion membrane,Single-pass membrane protein,Cytoplasmic side.,[Isoform 1]: Mitochondrion membrane,Single-pass membrane protein,Cytoplasmic side.,[Isoform 3]: Mitochondrion membrane,Single-pass membrane protein,Cytoplasmic side.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.