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NUR77 Rabbit mAb [3SL7]Cat NO.: A27023

Western blot(SDS PAGE) analysis of extracts from  Jurkat cells treated 40nM TPA and 2uM calcium ionophore A23187 for 4 hours.Using NUR77Rabbit mAb [3SL7] at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :NR4A1,GFRP1,HMR,NAK1,NR4A1_HUMAN,Nuclear receptor subfamily 4 group A member 1

UniProtID :P22736

MASS(da) :64,463

MW(kDa) :32,38,60-80 kDa

Form :Liquid

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity :Human

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human NUR77

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected : Jurkat cells treated 40nM TPA and 2uM calcium ionophore A23187 for 4 hours

Function : Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity)..

Tissue specificity :Fetal muscle and adult liver, brain and thyroid.

Subcellular locationi :Nucleus. Cytoplasm. Mitochondrion.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.