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Western blot(SDS PAGE) analysis of extracts from SH-SY5Y cells.Using IP3 receptorRabbit mAb [M31P] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :ITPR1,INSP3R1,ITPR1_HUMAN,Inositol 1,4,5-trisphosphate receptor type 1
UniProtID :Q14643
MASS(da) :313,929
MW(kDa) :314KD kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human IP3 receptor
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :SH-SY5Y cells
Function : Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity)..
Tissue specificity :Widely expressed..
Subcellular locationi :Endoplasmic reticulum membrane,Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane,Multi-pass membrane protein. Cytoplasm, perinuclear region.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.