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IFFO1 Rabbit mAb [3SG7]Cat NO.: A99757

Western blot(SDS PAGE) analysis of extracts from HEK-293T cells .Using IFFO1Rabbit mAb [3SG7] at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :IFFO1,IFFO,IFFO1_HUMAN,Non-homologous end joining factor IFFO1

UniProtID :Q0D2I5

MASS(da) :61,979

MW(kDa) :75  kDa

Form :Liquid

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity :Human

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human IFFO1

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :HEK-293T cells 

Function : Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606)..

Tissue specificity :Ubiquitously expressed..

Subcellular locationi :Nucleus. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus matrix.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.