TNF Receptor I Rabbit mAb [417E]Cat NO.: A26314

Protein names ：TNFRSF1A,TNFAR,TNFR1,TNR1A_HUMAN,Tumor necrosis factor receptor superfamily member 1A [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form,Tumor necrosis factor-binding protein 1 ]

UniProtID ：P19438

MASS(da) ：50,495

MW(kDa) ：50-70 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human TNF Receptor I

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Wild-type HeLa cells

Function ： Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

Subcellular locationi ：Cell membrane,Single-pass type I membrane protein. Golgi apparatus membrane,Single-pass type I membrane protein. Secreted.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.