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Western blot(SDS PAGE) analysis of extracts from Human liver.Using alpha 1 AntitrypsinRabbit mAb [67F1] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :SERPINA1,AAT,PI,PRO0684,PRO2209,A1AT_HUMAN,Alpha-1-antitrypsin [Cleaved into: Short peptide from AAT ]
UniProtID :P01009
MASS(da) :46,737
MW(kDa) :51,55 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human alpha 1 Antitrypsin
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected : Human liver
Function : Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin., [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
Tissue specificity :Ubiquitous. Expressed in leukocytes and plasma..
Subcellular locationi :Secreted. Endoplasmic reticulum.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.