Asialoglycoprotein Receptor 1/HL-1 Rabbit mAb [6542]Cat NO.: A22866

Protein names ：ASGR1,CLEC4H1,ASGR1_HUMAN,Asialoglycoprotein receptor 1

UniProtID ：P07306

MASS(da) ：33,186

MW(kDa) ：40-50 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• 免疫荧光(ICC/IF) 1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human Asialoglycoprotein Receptor 1/HL-1

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Human adult liver 

Function ： Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Tissue specificity ：Expressed exclusively in hepatic parenchymal cells.

Subcellular locationi ：[Isoform H1a]: Membrane,Single-pass type II membrane protein.,[Isoform H1b]: Secreted.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.