CLN5 Rabbit mAb [YN95]Cat NO.: A58348

Protein names ：CLN5,CLN5_HUMAN,Ceroid-lipofuscinosis neuronal protein 5 [Cleaved into: Ceroid-lipofuscinosis neuronal protein 5, secreted form]

UniProtID ：O75503

MASS(da) ：41,497

MW(kDa) ：48-52 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human CLN5

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：HepG2 cells 

Function ： Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521)..

Tissue specificity ：Ubiquitous.

Subcellular locationi ：[Ceroid-lipofuscinosis neuronal protein 5, secreted form]: Lysosome.,[Ceroid-lipofuscinosis neuronal protein 5]: Membrane,Single-pass type II membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.