Angiotensinogen Rabbit mAb [42UJ]Cat NO.: A75385

Protein names ：AGT,SERPINA8,ANGT_HUMAN,Angiotensinogen [Cleaved into: Angiotensin-1 ,Angiotensin-2 ,Angiotensin-3 ,Angiotensin-4 ,Angiotensin 1-9,Angiotensin 1-7,Angiotensin 1-5,Angiotensin 1-4]

UniProtID ：P01019

MASS(da) ：52,070

MW(kDa) ：48-70 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human Angiotensinogen

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Human plasma

Function ： Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis., [Angiotensin-2]: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Binds the DEAR/FBXW7-AS1 receptor (By similarity).., [Angiotensin-3]: Stimulates aldosterone release., [Angiotensin 1-7]: Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets..

Tissue specificity ：Expressed by the liver and secreted in plasma.

Subcellular locationi ：Secreted.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.