DC-SIGN + DC-SIGNR Rabbit mAb [4FI9]Cat NO.: A13506

Protein names ：CLEC4M,CD209L,CD209L1,CD299,CLC4M_HUMAN,C-type lectin domain family 4 member M

UniProtID ：Q9H2X3,Q9NNX6

MASS(da) ：45,350

MW(kDa) ：48,66 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• 免疫荧光(ICC/IF) 1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human DC-SIGN + DC-SIGNR

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Human thymus 

Function ： Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.., (Microbial infection) Acts as an attachment receptor for Ebolavirus.., (Microbial infection) Acts as an attachment receptor for Hepatitis C virus.., (Microbial infection) Acts as an attachment receptor for HIV-1.., (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.., (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.., (Microbial infection) Acts as an attachment receptor for Influenzavirus.., (Microbial infection) Acts as an attachment receptor for SARS-CoV.., (Microbial infection) Acts as an attachment receptor for West-nile virus.., (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.., (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.., (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule..

Tissue specificity ：Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells..

Subcellular locationi ：[Isoform 1]: Cell membrane,Single-pass type II membrane protein.,[Isoform 2]: Cell membrane,Single-pass type II membrane protein.,[Isoform 3]: Cell membrane,Single-pass type II membrane protein.,[Isoform 5]: Secreted.,[Isoform 6]: Secreted.,[Isoform 7]: Secreted.,[Isoform 10]: Secreted.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.