CEACAM5 + CD66b + CEACAM1 + CEACAM6 Rabbit mAb [5T31]Cat NO.: A78414

Protein names ：CEACAM5,CEA,CEAM5_HUMAN,Carcinoembryonic antigen-related cell adhesion molecule 5

UniProtID ：P06731,P13688,P31997,P40199

MASS(da) ：37,237

MW(kDa) ：110-150,75-90 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• 免疫荧光(ICC/IF) 1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human CEACAM5 + CD66b + CEACAM1 + CEACAM6

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ： human CEACAM5 recombinant protein 

Function ： Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression,induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).., (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer..

Tissue specificity ：Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon..

Subcellular locationi ：Cell membrane,Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.