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Western blot(SDS PAGE) analysis of extracts from Human lymph node.Using LYVE1Rabbit mAb [45Z2] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :LYVE1,CRSBP1,HAR,XLKD1,UNQ230/PRO263,LYVE1_HUMAN,Lymphatic vessel endothelial hyaluronic acid receptor 1
UniProtID :Q9Y5Y7
MASS(da) :35,213
MW(kDa) :50-70 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human LYVE1
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :Human lymph node
Function : Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10037799). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460)..
Tissue specificity :Mainly expressed in endothelial cells lining lymphatic vessels..
Subcellular locationi :Cell membrane,Single-pass type I membrane protein.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.