* 产品详情- */>
Western blot(SDS PAGE) analysis of extracts from A-375 cells .Using SOX10Rabbit mAb [DJ1L] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :SOX10,SOX10_HUMAN,Transcription factor SOX-10
UniProtID :P56693
MASS(da) :49,911
MW(kDa) :56-75 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human SOX10
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected : A-375 cells
Function : Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity)..
Tissue specificity :Expressed in fetal brain and in adult brain, heart, small intestine and colon.
Subcellular locationi :Cytoplasm. Nucleus. Mitochondrion outer membrane,Peripheral membrane protein,Cytoplasmic side.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.