DMT1/SLC11A2 Rabbit mAb [993B]Cat NO.: A73875

Protein names ：SLC11A2,DCT1,DMT1,NRAMP2,OK/SW-cl.20,NRAM2_HUMAN,Natural resistance-associated macrophage protein 2

UniProtID ：P49281

MASS(da) ：62,266

MW(kDa) ：55,70-100 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human DMT1/SLC11A2

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：SK-MEL-5 cells

Function ： Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria..

Tissue specificity ：Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney..

Subcellular locationi ：[Isoform 2]: Cell membrane,Multi-pass membrane protein. Early endosome.,Endosome membrane,Multi-pass membrane protein. Mitochondrion outer membrane,Multi-pass membrane protein. Cell membrane,Multi-pass membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.