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Western blot(SDS PAGE) analysis of extracts from rat brain.Using PEX19Rabbit mAb [IZ2H] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :PEX19,HK33,PXF,OK/SW-cl.22,PEX19_HUMAN,Peroxisomal biogenesis factor 19
UniProtID :P40855
MASS(da) :32,807
MW(kDa) :35,40 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human,Rat
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human PEX19
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :rat brain
Function : Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53..
Tissue specificity :Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form..
Subcellular locationi :Cytoplasm. Peroxisome membrane,Lipid-anchor,Cytoplasmic side.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.