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REC8 Rabbit mAb [60X4]Cat NO.: A93426

Western blot(SDS PAGE) analysis of extracts from rat testis .Using REC8Rabbit mAb [60X4] at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :REC8,REC8L1,REC8_HUMAN,Meiotic recombination protein REC8 homolog

UniProtID :O95072

MASS(da) :62,614

MW(kDa) :62 kDa

Form :Liquid

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity :Human,Mouse,Rat

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • 免疫组化(IHC)1:100
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human REC8

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :rat testis 

Function : Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity)..

Tissue specificity :Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa (at protein level)..

Subcellular locationi :Nucleus. Chromosome. Chromosome, centromere.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.