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Western blot(SDS PAGE) analysis of extracts from HepG2 cells .Using PAX6Rabbit mAb [2OCE] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :PAX6,AN2,PAX6_HUMAN,Paired box protein Pax-6
UniProtID :P26367
MASS(da) :46,683
MW(kDa) :47 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human,Mouse,Rat
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human PAX6
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :HepG2 cells
Function : Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity)..
Tissue specificity :[Isoform 1]: Expressed in lymphoblasts..,[Isoform 5a]: Weakly expressed in lymphoblasts..
Subcellular locationi :Nucleus.,[Isoform 1]: Nucleus.,[Isoform 5a]: Nucleus.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.