HB-EGF Rabbit mAb [5L28]Cat NO.: A50868

Protein names ：HBEGF,DTR,DTS,HEGFL,HBEGF_HUMAN,Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor ]

UniProtID ：Q99075

MASS(da) ：23,067

MW(kDa) ：25

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human HB-EGF.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 134% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：293T cells

Function ： Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Subcellular locationi ：[Heparin-binding EGF-like growth factor]: Secreted, extracellular space.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.