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Western blot(SDS PAGE) analysis of extracts from Mouse liver.Using TTC11/FIS1 Rabbit mAb [578U] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :FIS1,TTC11,CGI-135,FIS1_HUMAN,Mitochondrial fission 1 protein
UniProtID :Q9Y3D6
MASS(da) :16,938
MW(kDa) :15
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human,Mouse,Rat
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human TTC11/FIS1.
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 165% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :Mouse liver
Function : Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission..
Subcellular locationi :Mitochondrion outer membrane,Single-pass membrane protein. Peroxisome membrane,Single-pass membrane protein.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.