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ACVRL1 Rabbit mAb[8ZUB]Cat NO.: A58558

Western blot(SDS PAGE) analysis of extracts from 293T cells.Using ACVRL1 Rabbit mAb IgG [8ZUB] at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :ACVRL1,ACVRLK1,ALK1,ACVL1_HUMAN,Serine/threonine-protein kinase receptor R3

UniProtID :P37023

MASS(da) :56,124

MW(kDa) :60kDa

Form :Liquid

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity :Human,Mouse,Rat

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000,
  • 免疫荧光(ICC/IF) 1:100
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide of human ACVRL1.

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :293T cells

Function : Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well..

Subcellular locationi :Cell membrane,Single-pass type I membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.