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Western blot(SDS PAGE) analysis of extracts from HeLa cells.Using beta 2 Microglobulin Rabbit mAb IgG [F942] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :B2M,CDABP0092,HDCMA22P,B2MG_HUMAN,Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
UniProtID :P61769
MASS(da) :13,715
MW(kDa) :14KDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human,Mouse,Rat
Specificity :Antibody is produced by immunizing animals with a synthetic peptide of human beta 2 Microglobulin.
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :HeLa cells
Function : Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553)..
Subcellular locationi :Secreted. Cell surface.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.