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Western blot(SDS PAGE) analysis of extracts from Mouse lung tissue lysate.Using Caveolin-2Rabbit mAb IgG [W062] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :CAV2,CAV2_HUMAN,Caveolin-2
UniProtID :P51636
MASS(da) :18,291
MW(kDa) :21KDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human,Mouse
Specificity :Antibody is produced by immunizing animals with a synthetic peptide of human Caveolin-2 .
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :Mouse lung tissue lysate
Function : May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity)..
Tissue specificity :Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts..
Subcellular locationi :Nucleus. Cytoplasm. Golgi apparatus membrane,Peripheral membrane protein. Cell membrane,Peripheral membrane protein. Membrane, caveola,Peripheral membrane protein.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.