* 产品详情- */>
Western blot(SDS PAGE) analysis of extracts from Mouse heart tissue lysate.Using DR5/TRAILR2/TNFRSF10B Rabbit mAb IgG [1ZQ9] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :TNFRSF10B,DR5,KILLER,TRAILR2,TRICK2,ZTNFR9,UNQ160/PRO186,TR10B_HUMAN,Tumor necrosis factor receptor superfamily member 10B
UniProtID :O14763
MASS(da) :47,878
MW(kDa) :48kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human,Mouse,Rat
Specificity :Antibody is produced by immunizing animals with a synthetic peptide of human DR5/TRAILR2/TNFRSF10B.
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :Mouse heart tissue lysate
Function : Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis..
Tissue specificity :Widely expressed in adult and fetal tissues,very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361,highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract,not detectable in brain.
Subcellular locationi :Membrane,Single-pass type I membrane protein.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.