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DYNLL1 Rabbit mAb[IXHI]Cat NO.: A31436

Western blot(SDS PAGE) analysis of extracts from HeLa cells.Using DYNLL1 Rabbit mAb IgG [IXHI] at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :DYNLL1,DLC1,DNCL1,DNCLC1,HDLC1,DYL1_HUMAN,Dynein light chain 1, cytoplasmic

UniProtID :P63167

MASS(da) :10,366

MW(kDa) :10KDa

Form :Liquid

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity :Human,Mouse,Rat

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000,
  • 免疫组化(IHC)1:100
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide of human DYNLL1.

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :HeLa cells

Function : Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures., Binds and inhibits the catalytic activity of neuronal nitric oxide synthase., Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.., Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity..

Tissue specificity :Ubiquitous (PubMed:8628263). Expressed in testis (PubMed:22965910)..

Subcellular locationi :Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Nucleus. Mitochondrion.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.