FKBP38/FKBP8 Rabbit mAb[48ZJ]Cat NO.: A72570

Protein names ：FKBP8,FKBP38,FKBP8_HUMAN,Peptidyl-prolyl cis-trans isomerase FKBP8

UniProtID ：Q14318

MASS(da) ：44,562

MW(kDa) ：49KDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000,
• 免疫荧光(ICC/IF) 1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide of human FKBP38/FKBP8.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：HepG2 cells

Function ： Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis..

Tissue specificity ：Widely expressed. Highest levels seen in the brain. Highly abundant in the retina..

Subcellular locationi ：Mitochondrion. Mitochondrion membrane,Single-pass membrane protein,Cytoplasmic side.,[Isoform 1]: Mitochondrion membrane,Single-pass membrane protein,Cytoplasmic side.,[Isoform 3]: Mitochondrion membrane,Single-pass membrane protein,Cytoplasmic side.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.