GBP5 Rabbit mAb [Y448]Cat NO.: A64507

Protein names ：GBP5,UNQ2427/PRO4987,GBP5_HUMAN,Guanylate-binding protein 5

UniProtID ：Q96PP8

MASS(da) ：66,617

MW(kDa) ：67 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human GBP5

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：THP-1 cells differentiated with TPA (80 nM overnight) and then treated with LPS and hIFN-γ (both at 100 ng/ml 16 hr)

Function ： As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847)..

Tissue specificity ：Expressed in peripheral blood monocytes (at protein level)..

Subcellular locationi ：Cytoplasm. Golgi apparatus membrane,Lipid-anchor. Cytoplasmic vesicle.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.