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Western blot(SDS PAGE) analysis of extracts from HeLa cells.Using PGC1 beta Rabbit mAb IgG [854H] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :PPARGC1B,PERC,PGC1,PGC1B,PPARGC1,PRGC2_HUMAN,Peroxisome proliferator-activated receptor gamma coactivator 1-beta
UniProtID :Q86YN6
MASS(da) :113,222
MW(kDa) :113kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human,Mouse,Rat
Specificity :Antibody is produced by immunizing animals with a synthetic peptide of human PGC1 beta.
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :HeLa cells
Function : Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner..
Tissue specificity :Ubiquitous with higher expression in heart, brain and skeletal muscle..
Subcellular locationi :Nucleus.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.