CDK5R1 Mouse mAb[M9T8]Cat NO.: A81164

Protein names ：CDK5R1,CDK5R,NCK5A,CD5R1_HUMAN,Cyclin-dependent kinase 5 activator 1 [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 ,Cyclin-dependent kinase 5 activator 1, p25 ]

UniProtID ：Q15078

MASS(da) ：34,060

MW(kDa) ：34kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Mouse

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide of human CDK5R1.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：mouse cerebellum tissue

Function ： p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution..

Tissue specificity ：Brain and neuron specific.

Subcellular locationi ：[Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane,Lipid-anchor,Cytoplasmic side. Cell projection, neuron projection.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.