MFG-E8 Mouse mAb[C69Q]Cat NO.: A34534

Protein names ：MFGE8,MFGM_HUMAN,Lactadherin [Cleaved into: Lactadherin short form,Medin]

UniProtID ：Q08431

MASS(da) ：43,105

MW(kDa) ：43kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Mouse

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide of human MFG-E8.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：human milk

Function ： Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.., [Medin]: Main constituent of aortic medial amyloid..

Tissue specificity ：Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.

Subcellular locationi ：Membrane,Peripheral membrane protein. Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome membrane,Peripheral membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.