PGRMC1 Mouse mAb[ZZZV]Cat NO.: A44389

Protein names ：PGRMC1,HPR6.6,PGRMC,PGRC1_HUMAN,Membrane-associated progesterone receptor component 1

UniProtID ：O00264

MASS(da) ：21,671

MW(kDa) ：25kda

Form ：Liquid

Purification ：Protein A purification

Host ：Mouse

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• 免疫荧光(ICC/IF) 1:100,
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide of human PGRMC1.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：A549 cells

Function ： Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036)..

Tissue specificity ：Widely expressed, with highest expression in liver and kidney. Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472)..

Subcellular locationi ：Microsome membrane,Single-pass membrane protein. Smooth endoplasmic reticulum membrane,Single-pass membrane protein. Mitochondrion outer membrane,Single-pass membrane protein,Extracellular side.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.