Synaptotagmin-1 Mouse mAb[T178]Cat NO.: A65501

Protein names ：SYT1,SVP65,SYT,SYT1_HUMAN,Synaptotagmin-1

UniProtID ：P21579

MASS(da) ：47,573

MW(kDa) ：60kda

Form ：Liquid

Purification ：Protein A purification

Host ：Mouse

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide of human Synaptotagmin-1.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：rat cerebellum tissue

Function ： Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner,these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003)..

Tissue specificity ：Expressed in melanocytes (PubMed:23999003)..

Subcellular locationi ：Cytoplasmic vesicle, secretory vesicle membrane,Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane,Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane,Single-pass membrane protein. Cytoplasm.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.