IL-4R Mouse mAb[L2F4]Cat NO.: A21401

Protein names ：IL4R,IL4RA,582J2.1,IL4RA_HUMAN,Interleukin-4 receptor subunit alpha [Cleaved into: Soluble interleukin-4 receptor subunit alpha ]

UniProtID ：P24394

MASS(da) ：89,658

MW(kDa) ：120kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Mouse

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide of human IL-4R.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Jurkat cells

Function ： Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.., Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells..

Tissue specificity ：Isoform 1 and isoform 2 are highly expressed in activated T-cells.

Subcellular locationi ：Cell membrane,Single-pass type I membrane protein.,[Isoform 2]: Secreted.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.